However, some secondary measures of nerve impairment did improve, especially in participants with higher cardiovascular risk and moderate BMI.7 Shorter-term trials have shown that 600mg/day of oral racemic ALA reduced neuropathy symptoms like burning, tingling, and numbness in as little as 35 weeks.4 20 A 2010 meta-analysis concluded that oral ALA can improve symptoms of diabetic neuropathy, but noted variability in effect sizes across trials and better results with intravenous administration.1 Despite promising results from some trials, a recent systematic review evaluating eight randomized controlled trials indicates that findings on ALA's effectiveness in treating diabetic neuropathy symptoms are inconsistent.23 While ALA proved safe and tolerable across these studies, the review concluded that definitive evidence supporting significant benefits is limited
Svensson et al., The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats, J
doi:10.1186/s12905-025-03798-w Neri LCL, Quintiero F, Fiorini S, et al
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Thus, further research is crucial to expand effective therapies, particularly those targeting metabolic dysfunction and improving clinical outcomes
Your doctor can help determine if it is appropriate for your specific needs and ensure it fits safely into your prenatal routine
